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Staurosporine (CAS 62996-74-1)

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Synonym:ANTIBIOTIC M 193; ANTIBIOTIC AM-2282
Application:An inhibitor of PKA, PKG, PKC, CaMK, tyrosine kinases, and phosphorylase kinase
CAS Number:62996-74-1
Purity:>99%
Molecular Weight:466.5
Molecular Formula:C28H26N4O3
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Staurosporine sc-3510 100 µg $77
Staurosporine sc-3510A 1 mg $199
Description
Staurosporine, a microbial alkaloid with antifungal activity, has been shown to inhibit a variety of kinases including PKA (Ki=7.0 nM), PKG (Ki=8.5 nM), MLCK (Ki=1.3 nM), PKC (Ki=0.7 nM), CaMK (IC50=20 nM), CAMKII (Ki=20nM) tyrosine kinases (IC50=70 nM) and phosphorylase kinase (IC50=0.5 nM). Inhibition is via interaction with the ATP binding site. It induces PKC translocation, induces association of purified PKC with inside-out vesicles from erythrocyte membranes and augments PMA-induced ornithine decarboxylase. Activates a bcl-2-regulated apoptosis pathway.
Technical Information
Appearance:Lyophilized solid
Physical State:Solid
Derived from:Streptomyces sp. MST-AS5345
Solubility:Soluble in DMSO (25 mg/ml), DMF (25 mg/ml), ethyl acetate, hot acetone, and ethanol. Slightly soluble in chloroform, and methanol, Insoluble in water.
Storage:Store at 4° C
Melting Point:270 °C (dec.)
Boiling Point:677.52 °C at 760 mmHg
Density:1.56 g/cm3
Refractive Index:n20D 1.81
IC50:Chk1: IC50 = <0.5 nM (human); Akt3: IC50 = 0.64 nM (human); phosphorylase kinase: IC50 = 0.5 nM; Tyrosine-protein kinase SRC: IC50 = 1.0 nM (human); AMPK: IC50 = <1.0 nM (human)
Safety and Reference Information
RTECS:KD5084000
PubChem CID:44259
Merck Index:14: 8802
MDL Number:MFCD00077402
SMILES:CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Tamaoki, T., et al. 1986. Biochem. Biophys. Res. Commun. 135: 397-402. PMID: 3457562
2. Wolf, M., et al. 1988. Biochem. Biophys. Res. Commun. 154: 1273-1279. PMID: 3408497
3. Matsumoto, H., et al. 1989. Biochem. Biophys. Res. Commun. 158: 105-109. PMID: 2912441
4. Fallon, R.J. 1990. Biochem. Biophys. Res. Commun. 170: 1191-1196. PMID: 2167672
5. Elliott, L.H., et al. 1990. Biochem. Biophys. Res. Commun. 171: 148-154. PMID: 2393389
6. Badwey, J.A., et al. 1991. Biochem. Biophys. Res. Commun. 178: 423-429. PMID: 1859401
7. Yanagihara, N., et al. 1991. J. Neurochem. 56: 294-298. PMID: 1846174
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