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CNG-β3 Antibody (N-20): sc-34993

 |  Datasheet

(Based on data analysis)
  • CNG-β3 Antibody (N-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an N-terminal cytoplasmic domain of CNG-β3 of human origin
  • recommended for detection of CNG-β3 of human origin by WB, IF and ELISA
  • blocking peptide, sc-34993 P
 

See additional CNG Antibodies including CNG, CNG-1, CNG-1beta, CNG-2, CNG-3, CNG-beta 3 and CNG-4.

Also see CNG Activators for functional analysis of cellular responses to CNG.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3 Antibody (N-20) sc-34993 200 µg/ml $279
CNG-β3 (N-20) P sc-34993 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3 siRNA (h) sc-45563 10 µM $258
CNG-β3siRNA (h)-PR sc-45563-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3siRNA shRNA Plasmid (h) sc-45563-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3siRNA shRNA (h) Lentiviral Particles sc-45563-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Y79 Cell Lysate sc-2240 500 µg/200 µl $104
T98G Cell Lysate sc-2294 500 µg/200 µl $104
H4 Cell Lysate sc-2408 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CNGB3 54714 8q21.3 NM_019098 Q9NQW8
 605080
 

Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits. The alpha (å) subunits consist of CNG1-3 and form functional cation channels by themselves. The beta (∫) subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels. formed by CNG1-3. CNG channels are essential components of olfactory and visual transduction. CNG proteins are present in cone and rod photoreceptors and in the pineal gland, and they contribute to modulating arterial blood pressure. CNG6, also designated cyclic-nucleotide-gated cation channel beta 3 (CNG-∫3), is an integral membrane protein that can form a heterooligomeric complex with CNG-3. CNG-∫3 is activated by cGMP and this activation leads to the depolarization of rod photoreceptors as a result of cation channel being opened. CNG-∫3 is expressed in a small group of retinal photoreceptor cells and in testis. Mutations in the gene encoding for CNG-∫3, can cause achromatopsia, an autosomal recessively inherited disease characterized by low visual acuity, photophobia, a lack of color discrimination, and nystagmus.