 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of AFX1 of mouse origin
- recommended for detection of AFX1 of mouse and rat origin by WB, IP, IF and ELISA
- blocking peptide, sc-348900 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-34900 X, 200 µg/0.1 ml
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
Foxo4 |
54601 |
X C3 |
|
Q9WVH3
|
N/A |
| |
AFX1 Background Information
FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.
|
|
|
AFX1 (N-13)
Click on image to enlarge
|
|
AFX1 (N-13): sc-34900. Western blot analysis of AFX1 expression in NIH/3T3 nuclear extract.
|
|
Download
|
|
