 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of HNF-3γ of human origin
- recommended for detection of HNF-3γ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
- blocking peptide, sc-34622 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-34622 X, 200 µg/0.1 ml
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
FOXA3 |
3171 |
19q13.32 |
NM_004497 |
P55318
|
602295 |
| Mouse |
Foxa3 |
15377 |
7 A3 |
|
P35584
|
N/A |
| |
FOXA3 Background Information
HNF-1 (å and ∫), HNF-3 (å, ∫ and ©), HNF-4 (å and ©), and HNF-6 compose, in part, a homeoprotein family designated the Hepatocyte Nuclear Factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3å, HNF-3∫ and HNF-3© regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3å and HNF-3∫ have also been shown to be involved in gastrulation events such as body axis formation. HNF-4å and HNF-4© have been shown to be important for early embryo development. HNF-4å is expressed in liver, kidney, pancreas, small intestine, testis and colon; HNF-4© is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3∫, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and å-1 antitrypsin. |
|
|
HNF-3γ (N-14)
Click on image to enlarge
|
HNF-3γ (N-14): sc-34622. Western blot analysis of HNF-3γ expression in non-transfected: sc-110760 (A) and human HNF-3γ transfected: sc-111854 (B) 293 whole cell lysates. |
|
Download
|
|
