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Stat1 p84/p91 (E-23) Antibody: sc-346 |
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- rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-346-G
- epitope mapping near the C-terminus of Stat1 p84/p91 of human origin
- recommended for detection of Stat1β p84 and Stat1α p91 of mouse, rat, human and Xenopus origin by WB, IP, IF, FCM and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-346 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-346 X, 200 µg/0.1 ml
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Stat1 p84/p91 Background Information
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-å and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
| Stat1 p84/p91 (E-23) Product Citations |
See how others have used Stat1 p84/p91 (E-23): sc-346 antibody and or Stat1 p84/p91 (E-23) antibody conjugates.
164 total citations Loading citations.
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Stat1 p84/p91 (E-23)
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Western blot analysis of Stat1α p91 and Stat1β p84 expression in nuclear extracts of phorbol ester-treated HeLa (A,D), A-431 (B,E) and K-562 (C,F) cells. Antibodies include Stat1α p91 (C-24): sc-345 (AC) and Stat1 p84/p91 (E-23): sc-346 (DF). Stat1 p84/p91 (E-23): sc-346. FCM analysis of LPS-treated BAlb/c cells. Kindly provided by Dr. Subhashini Arimilli at Wake Forest University Baptist Medical Center.
Stat1 p84/p91 (E-23): sc-346. Western blot analysis of Stat1 p84/p91 expression in non-transfected 293T: sc-117752 (A), mouse Stat1 p84/p91 transfected 293T: sc-123815 (B) and HeLa (C) whole cell lysates. Stat1 p84/p91 (E-23): sc-346. Western blot analysis of Stat1 p84/p91 expression in non-transfected 293T: sc-117752 (A), mouse Stat1 p84/p91 transfected 293T: sc-123816 (B) and HeLa (C) whole cell lysates. Stat1 p84/p91 (E-23): sc-346. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.
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