epitope mapping near the C-terminus of COP1 of human origin
recommended for detection of COP1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-34592 X, 200 µg/0.1 ml
COP1 Background Information COP1 (Constitutive photomorphogenesis protein 1), also designated RFWD2 (ring finger and WD repeat domain 2) or RNF200 (ring finger protein 200), is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.
COP1 (K-16) Product Citations
See how others have used COP1 (K-16): sc-34592 antibody and or COP1 (K-16) antibody conjugates.
