epitope mapping near the N-terminus of LRF of human origin
recommended for detection of LRF of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
blocking peptide, sc-34510 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-34510 X, 200 µg/0.1 ml
LRF Background Information LRF, formerly identified as Pokemon, is a poxvirus zinc finger (POZ) domain-containing transcription factor that influences cell differentiation. LRF (for leukemia/lymphoma related factor) is also known as zinc finger and BTB domain containing 7A, ZBTB7, TIP21, FBI1 and FBI-1. POZ-domain transcription factors contain a POZ or BTB type protein-protein interaction domain at their N-terminus and Kruppel-type zinc fingers at their C-terminus. LRF is inducible during both murine and human preadipocyte differentiation and may contrib-ute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation. LRF can associate with active chromatin and stimulate TAT-activated HIV-1 transcription through interactions with the HIV-1 long terminal repeat. 3T3L1 cells stably overexpressing LRF show a reduction in DNA synthesis and in expression of cyclin A, cyclin-dependent kinase 2 and p107.
LRF (E-15)
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LRF (E-15): sc-34510. Western blot analysis of LRF expression in Hep G2 nuclear extract.
