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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-34479-R
- epitope mapping at the C-terminus of JAK2 of human origin
- recommended for detection of JAK2 of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including equine, canine, bovine, porcine and avian
- preferred WB antibody
- blocking peptide, sc-34479 P
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JAK2 Background Information
JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
| JAK2 (C-14) Product Citations |
See how others have used JAK2 (C-14): sc-34479 antibody and or JAK2 (C-14) antibody conjugates.
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JAK2 (C-14)
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JAK2 (C-14): sc-34479. Western blot analysis of JAK2 expression in CCRF-CEM whole cell lysate.
JAK2 (C-14): sc-34479. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
JAK2 (C-14): sc-34479. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.
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