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GC-C Antibody (K-14): sc-34426

 |  Datasheet

(Based on data analysis)

  • GC-C Antibody (K-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of GC-C of human origin
  • recommended for detection of GC-C of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
  • blocking peptide, sc-34426 P
 

See additional Guanylate Cyclases Antibodies.

Also see chemical Guanylate Cyclases Inhibitors or chemical Guanylate Cyclases Activators for functional analysis of cellular responses to Guanylate Cyclases.


Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C Antibody (K-14) sc-34426 200 µg/ml $279
GC-C (K-14) P sc-34426 P
(peptide)
100 µg/0.5 ml $61
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C CRISPR/Cas9 KO Plasmid (h) sc-403413 20 µg $345
GC-C HDR Plasmid (h) sc-403413-HDR 20 µg $385
GC-C CRISPR/Cas9 KO Plasmid (m) sc-420736 20 µg $345
GC-C HDR Plasmid (m) sc-420736-HDR 20 µg $385
Gucy2d CRISPR/Cas9 KO Plasmid (m) sc-420737 20 µg $345
Gucy2d HDR Plasmid (m) sc-420737-HDR 20 µg $385
Gucy2g CRISPR/Cas9 KO Plasmid (m) sc-428623 20 µg $345
Gucy2g HDR Plasmid (m) sc-428623-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C siRNA (h) sc-45492 10 µM $258
GC-C siRNA (m) sc-45493 10 µM $258
GC-C siRNA (r) sc-270310 10 µM $258
GC-C (h)-PR sc-45492-PR 10 µM, 20 µl $23
GC-C (m)-PR sc-45493-PR 10 µM, 20 µl $23
GC-C (r)-PR sc-270310-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA Plasmid (h) sc-45492-SH 20 µg $520
GC-C shRNA Plasmid (m) sc-45493-SH 20 µg $520
GC-C shRNA Plasmid (r) sc-270310-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA (h) Lentiviral Particles sc-45492-V 200 µl $625
GC-C shRNA (m) Lentiviral Particles sc-45493-V 200 µl $625
GC-C shRNA (r) Lentiviral Particles sc-270310-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GUCY2C 2984 12p13.1 NM_004963 P25092
601330
Mouse Gucy2c 14917 6 G1 Q3UWA6
N/A
 


Guanylate Cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide, and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a precursor form present in the endoplasmic reticulum and a form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heat-stable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.