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GC-C Antibody (K-14): sc-34426

 |  Datasheet

(Based on data analysis)

  • GC-C Antibody (K-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of GC-C of human origin
  • recommended for detection of GC-C of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
  • blocking peptide, sc-34426 P

See additional Guanylate Cyclases Antibodies.

Also see Guanylate Cyclases Inhibitors or Guanylate Cyclases Activators for functional analysis of cellular responses to Guanylate Cyclases.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C Antibody (K-14) sc-34426 200 µg/ml $279
GC-C (K-14) P sc-34426 P
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C siRNA (h) sc-45492 10 µM $258
GC-C siRNA (m) sc-45493 10 µM $258
GC-C siRNA (r) sc-270310 10 µM $258
GC-C (h)-PR sc-45492-PR 10 µM, 20 µl $23
GC-C (m)-PR sc-45493-PR 10 µM, 20 µl $23
GC-C (r)-PR sc-270310-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA Plasmid (h) sc-45492-SH 20 µg $520
GC-C shRNA Plasmid (m) sc-45493-SH 20 µg $520
GC-C shRNA Plasmid (r) sc-270310-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA (h) Lentiviral Particles sc-45492-V 200 µl $625
GC-C shRNA (m) Lentiviral Particles sc-45493-V 200 µl $625
GC-C shRNA (r) Lentiviral Particles sc-270310-V 200 µl $625
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GUCY2C 2984 12p13.1 NM_004963 P25092
Mouse Gucy2c 14917 6 G1 Q3UWA6

Guanylate Cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide, and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a precursor form present in the endoplasmic reticulum and a form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heat-stable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.