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p-PC-PLD1 Antibody (Ser 2): sc-34388

 |  Datasheet

(Based on data analysis)
  • p-PC-PLD1 Antibody (Ser 2) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to phosphorylated at the N-terminus of p-PC-PLD1 of human origin
  • recommended for detection of Phospholipase D1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-34388 P
 

See additional PC-PLD Antibodies including PC-PLD, PC-PLD1, PC-PLD4, PC-PLD5, PC-PLD2 and PC-PLD3.

Also see PC-PLD Inhibitors or PC-PLD Activators for functional analysis of cellular responses to PC-PLD.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-PC-PLD1 Antibody (Ser 2) sc-34388 200 µg/ml $279
p-PC-PLD1 (Ser 2) P sc-34388 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PC-PLD1 siRNA (h) sc-44000 10 µM $258
PC-PLD1 siRNA (m) sc-41629 10 µM $258
PC-PLD1 siRNA (h) sc-44000-PR 10 µM, 20 µl $23
PC-PLD1 (m)-PR sc-41629-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PC-PLD1 shRNA Plasmid (h) sc-44000-SH 20 µg $520
PC-PLD1 shRNA Plasmid (m) sc-41629-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PC-PLD1 shRNA (h) Lentiviral Particles sc-44000-V 200 µl $625
PC-PLD1 shRNA (m) Lentiviral Particles sc-41629-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PLD1 5337 3q26.31 NM_002662 Q13393
 602382
Mouse Pld1 18805 3 A3 Q9Z280
 N/A
 

Virtually every cell uses phosphatidylcholine as a substrate to produce phosphatidic acid and choline. Phosphatidylcholine phospholipase D1 and D2 (PC-PLD1 and PC-PLD2) are phospholipid-specific phosphodiesterases that hydrolyze phosphatidylcholine. Unlike PC-PLD1, which associates with secretory granules, PC-PLD2 localizes to the plasma membrane, where it is implicated in the formation of endocytotic vesicles. Both PC-PLD1 and PC-PLD2 coordinately regulate macrophage phagocytosis. PC-PLD activity in mammalian cells is transiently stimulated upon activation by G protein-coupled and receptor tyrosine kinase cell surface receptors. For example, PC-PLD1 and PC-PLD2 participate in sphingosine 1-phosphate stimulation of ERK phosphorylation and IL-8 secretion in bronchial epithelial cells. In addition, tubulin binding to PC-PLD2 inhibits muscarinic receptor-linked PC-PLD2 activation. PC-PLD2 also enhances PKCzeta activity through direct interaction in a lipase activity-independent manner. PC-PLD1 and PC-PLD2 stimulate cell growth by repressing expression of p21 gene through p53-dependent and p53-independent pathways, respectively, which may ultimately lead to carcinogenesis.