HAX-1 (E-20) Antibody: sc-34273

HAX-1 Background Information
HAX-1 (HS1-associated protein X-1 or HS1-binding protein protein X-1), encodes a novel protein. HAX-1 has previously been shown to associate with HS1, a protein specifically expressed in cells of the hematopoietic lineage, and is thought to be involved in signal transduction in B cells and apoptosis. Though first identified as a protein that associates with HS1, recent data has also revealed interactions between HAX-1 and three disparate proteins: Polycystin-2 (derived from the PKD2 gene), a protein linked to polycystic kidney disease; Cortactin; and EBNA-LP (Epstein-Barr virus nuclear antigen leader protein). Additionally, HAX-1 has been identified as a binding partner to the carboxy-terminus of the K15 protein of Kaposi’s sarcoma-associated herpesvirus. K15 interacts with cellular HAX-1 in vitro and in vivo. Furthermore, HAX-1 co-localizes with K15 in the endoplasmic reticulum and mitochondria. Immunofluorescence experiments show that in most cells PKD2 and HAX-1 co-localize in the cell body, but in some cells PKD2 and HAX-1 also are sorted into cellular processes and lamellipodia. The HAX-1 gene is expressed ubiquitously among tissues. Its protein is localized mainly in mitochondria, but also in endoplasmic reticulum and the nuclear envelope of the cell.