epitope mapping within RNA binding domain 1 at the N-terminus of SRp55 of human origin
recommended for detection of SRp55 and SRp75 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including bovine, porcine and avian
SRp55 Background Information Pre-mRNA splicing is a critical step in the post-transcriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. Serine/arginine-rich (SR) proteins SRp55, SRp30c, and htra2beta1 regulate exon 2 and 10 splicing. The first two inhibit both exons and SRp55 also plays a role in exon inclusion after the removal of intronic splicing silencer sequences. SRp55 plays a major role in maintaining normal FGFR1 alpha-exon inclusion.
