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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of CDYL of human origin
- recommended for detection of CDYL of mouse, rat and human origin and, to a lesser extent, CDY of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-34148 P
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Ordering Information
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CDYL Background Information
CDY, a gene family expressed exclusively in the testis, localizes to a region of the Y chromosome frequently deleted in infertile males. CDY protein contains two functional domains, an N-terminal chromodomain, possibly functioning in heterochromatin interactions, and also a C-terminal domain which resembles enoyl-CoA-isomerase, a protein involved in fatty acid oxidation. Furthermore, CDY acts as a histone acetyltransferase, with strong preference for histone H4, a process required for the histone to proamine transition in spermatogenesis, consistent with the association with male infertility. Chromodomain Y-like protein (CDYL) is a related ubiquitous nuclear protein expressed at moderate levels in most tissues. The gene encoding for the CDYL protein localizes to chromosome 6p25.1.
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CDYL (G-15)
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CDYL (G-15): sc-34148. Western blot analysis of CDYL expression in F9 (A), NTERA-2 cl.D1 (B), COLO 320DM (C), AMJ2-C8 (D) whole cell lysates and rat testis tissue extract (E).
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