epitope corresponding to amino acids 589-888 mapping at the C-terminus of HMGCR of human origin
recommended for detection of HMGCR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
HMGCR Background Information The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
HMGCR (H-300) Product Citations
See how others have used HMGCR (H-300): sc-33827 antibody and or HMGCR (H-300) antibody conjugates.
8 total citations
Loading citations.
HMGCR (H-300)
Click on image to enlarge
HMGCR (H-300): sc-33827. Western blot analysis of HMGCR expression in non-transfected: sc-117752 (A) and mouse HMGCR transfected: sc-120842 (B) 293T whole cell lysates.
HMGCR (H-300): sc-33827. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and membrane localization.
