epitope corresponding to amino acids 1-89 representing full length barrier-to-autointegration factor of human origin
recommended for detection of barrier-to-autointegration factor of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-33787 X, 200 µg/0.1 ml
BAF Background Information Barrier-to-autointegration factor (BAF) binds non-specifically to double stranded DNA, possibly to play a role in tissue- or cell type-specific gene expression by interacting with different homeodomain transcription factors. BAF compresses chromatin structure and interacts with the LEM domain of nuclear proteins to play a crucial role in membrane recruitment and chromatin decondensation during nuclear assembly. Additionally, retroviruses like HIV-1 incorporate BAF from host cells into preintegration complexes (PICs) to prevent autointegration of retroviral DNA and thereby promote integration of retroviral DNA into the host chromosome.
BAF (FL-89)
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BAF (FL-89): sc-33787. Western blot analysis of BAF expression in HeLa nuclear extract.
BAF (FL-89): sc-33787. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing nuclear staining of stromal cells in low (A) and high (B) resolution. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
