epitope corresponding to amino acids 204-503 mapping at the C-terminus of NRF-1 of human origin
recommended for detection of NRF-1 long and short isoforms of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-33771 X, 200 µg/0.1 ml
NRF-1 Background Information Nuclear respiratory factor-1 (NRF-1) is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in mammalian cells. The NRF-1 gene is expressed during oogenesis and during the early stages of embryogenesis. In vitro studies have implicated NRF-1 in the transcriptional expression of nuclear genes required for mitochondrial respiratory function, as well as for other fundamental cellular activities. While most isolated wild-type and NRF-1+/- blastocysts continue to develop normally in vitro, NRF-1-/- blastocysts lack this ability, despite their normal morphology. NRF-1 is specifically required in the maintenance of mtDNA and respiratory chain function during early embryogenesis. NRF-1 also plays a key role in cellular adaptation to energy demands by translating physiological signals into an increased capacity for generating energy. Additionally, NRF-1 is a major transcription factor that binds the promoter in brain and testis.
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NRF-1 (H-300)
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NRF-1 (H-300): sc-33771. Immunofluorescence staining of normal mouse lymph node frozen section showing nuclear staining.
