Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Chemicals » Intermediates » 5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine ]: sc-336962

5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine ] (CAS 28797-48-0)

Application:Is an intermediate of Pirenzepine
CAS Number:28797-48-0
Molecular Weight:287.7
Molecular Formula:C14H10ClN3O2
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine ] sc-336962 10 g $373
Description
5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine] is an intermediate of Pirenzepine. Pirenzepine (sc-204197) is a selective antagonist for the M1 muscarinic receptor (mAChR) and is reported to block presynaptic M1 receptors as well as some reported inverse agonist activity. A study investigating the pharmacological characterization of the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a rabbit model of pulmonary hypertension determined the IC50 to be 2.51x10-7M. Additional research studies have investigated the role of Pirenzepine in the pathophysiology of myopia. Other M1 receptor antagonists offered include Telenzepine (sc-204332).
Safety and Reference Information
SMILES:ClCC(=O)n1c2ncccc2[nH]c(=O)c2ccccc12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Daeffler, L., et al. 1999. Br. J. Pharmacol. 126: 1246-1252. PMID: 10205015
2. Orii, R., et al. 2010. Biosci Trends. 4: 260-266. PMID: 21068480
3. Garcia, N., et al. 2010. J. Neurosci. 30: 16514-16522. PMID: 21147991
4. González, J.C., et al. 2011. Eur. J. Neurosci. 33: 69-81. PMID: 21091801
SDS
Related Product Categories