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home » Transcription Regulators » IRF Antibody / IRF Antibodies » IRF-3 (SL-14): sc-33642

IRF-3 (SL-14) Antibody: sc-33642

  |  Datasheet
  • mouse monoclonal IgG1; 200 µg/ml
  • raised against recombinant IRF-3 fusion protein corresponding to human IRF-3
  • recommended for detection of IRF-3 of human origin by WB and IP
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-33642 X, 200 µg/0.1 ml
 
Additional IRF Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human IRF3 3661 19q13.33 NM_001571 Q14653
 n/a
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-3 (SL-14) sc-33642 200 µg/ml $279
IRF-3 (SL-14) X sc-33642 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-3 siRNA (h) sc-35710 10 µM $258
IRF-3 (h)-PR sc-35710-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-3 shRNA Plasmid (h) sc-35710-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-3 shRNA (h) Lentiviral Particles sc-35710-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
U-937 nuclear extract sc-2156 1000 µg $143
IRF-3 (h): 293T Lysate sc-117389 100µg/200µl $205

IRF-3 Background Information
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-å and ∫) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-å and interferon-∫ genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3© p48 and IFN consensus sequence-binding protein (ICSBP).

IRF-3 (SL-14)
Click on image to enlarge
sc-33642
IRF-3 (SL-14): sc-33642. Western blot analysis of IRF-3 expression in Jurkat (A) and HL-60 (B) whole cell lysates and U-937 nuclear extract (C).
sc-33642
IRF-3 (SL-14): sc-33642. Western blot analysis of IRF-3 expression in non-transfected: sc-117752 (A) and human IRF-3 transfected: sc-117389 (B) 293T whole cell lysates.
sc-33642
IRF-3 (SL-14): sc-33642. Western blot analysis of IRF-3 expression in HeLa whole cell lysate.
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Datasheets
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