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AKAP 149/121 Antibody (H-300): sc-33576

 |  Datasheet

(Based on data analysis)

  • AKAP 149/121 Antibody (H-300) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 604-903 mapping at the C-terminus of AKAP 149 of human origin
  • recommended for detection of AKAP 149 of human origin and AKAP 121 of mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
 
Full-length AKAP 149/121 protein sequence with immunogen highlighted:
MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYYTSL

See additional AKAP Antibodies including AKAP 14, AKAP, AKAP 13, AKAP 149/121, AKAP 3, AKAP 7, AKAP 8L, AKAP 9, AKAP 10, AKAP 12, AKAP 79, AKAP 82, AKAP 95, AKAP 100, AKAP 121, AKAP 149, AKAP 150, AKAP 220, AKAP 2 and AKAP 250.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
AKAP 149/121 Antibody (H-300) sc-33576 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
AKAP 149 siRNA (h) sc-40301 10 µM $258
AKAP 121 siRNA (m) sc-40302 10 µM $258
AKAP 149 (h)-PR sc-40301-PR 10 µM, 20 µl $23
AKAP 121 (m)-PR sc-40302-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
AKAP 149 shRNA Plasmid (h) sc-40301-SH 20 µg $520
AKAP 121 shRNA Plasmid (m) sc-40302-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
AKAP 149 shRNA (h) Lentiviral Particles sc-40301-V 200 µl $625
AKAP 121 shRNA (m) Lentiviral Particles sc-40302-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human AKAP1 8165 17q22 NM_003488 Q92667
 602449
Mouse Akap1 11640 11 C O08715
 N/A
 

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization. AKAP 149, the human homolog of mouse and rat AKAP 121, is a splice variant of S-AKAP 84 and may be involved in the phosphorylation-dependent regulation of RNA processing.

AKAP 149/121 Antibody (H-300) Data
Click on image to enlarge
sc-33576
AKAP 149 (H-300): sc-33576. Western blot analysis of AKAP 149 expression in non-transfected: sc-117752 (A) and mouse AKAP 149 transfected: sc-178271 (B) 293T whole cell lysates.
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