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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-223 representing full length EMBP of mouse origin
- recommended for detection of EMBP, and, to a lesser extent, PRG3 of mouse and rat origin by WB, IP, IF and ELISA
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
Prg2 |
19074 |
2 D |
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Q61878
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N/A |
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EMBP Background Information
The eosinophil major basic protein (EMBP), also designated MBP, PRG2, proteoglycan 2, BMPG, or bone marrow natural killer cell activator, is a constituent of the crystalline core of the eosinophil granule. High levels of the pro-EMBP are present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT) and C3dg. EMBP may influence antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and may play a role in immune hypersensitivity reactions. EMBP stimulates an Src kinase-dependent activation of class I (A) phosphoinositide 3-kinase and, in turn, activation of protein kinase C Ω in neutrophils. EMBP transcription is under regulation by novel combinatorial interactions of GATA-1, PU.1, and C/EBPé isoforms. |
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EMBP (M-223)
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EMBP (M-223): sc-33557. Western blot analysis of EMBP expression in mouse spleen tissue extract.
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