MFG-E8 (M-135) Antibody: sc-33546

MFG-E8 Background Information
Human milk-fat globule (MFG) is abundant in human breast milk and is composed of secreted lipids encapsulated by plasma membranes from the epithelial cells of mammary glands. MFG membranes are composed of various glycoproteins that serve as markers for differentiated carcinomas. MFG-E8 (Milk fat globule-EGF factor 8), also known as Lactadherin or BA46, is a 387 amino acid peripheral membrane protein that localizes to the membrane of a variety of tissues, including mammary epithelial surfaces, and contains one EGF-like domain and two F5/8 type C domains. Functioning as a specific ligand for Integrin ∫5 and Integrin ∫3, MFG-E8 is thought to be involved in gamete interactions and cell attachment, possibly playing a role in fertilization and apoptosis. Additionally, MFG-E8 binds to rotavirus and inhibits its replication, thereby protecting the cell from viral infection. Overexpression of MFG-E8 is associated with breast cancer, suggesting that MFG-E8 may be related to tumorigenesis.