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OCTN1/2/3 (H-130) Antibody: sc-33534 |
| Datasheet |
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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-130 mapping at the N-terminus of OCTN2 of human origin
- recommended for detection of OCTN1 and 2 of mouse, rat and human origin, and OCTN3 of mouse origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
Slc22a5 |
20520 |
11 B1.3 |
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Q9Z0E8
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N/A |
| Mouse |
Slc22a4 |
30805 |
11 B1.3 |
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Q9Z306
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N/A |
| Mouse |
Slc22a21 |
56517 |
11 B1.3 |
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Q9WTN6
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N/A |
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OCTN1/2/3 Background Information
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia. |
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OCTN1/2/3 (H-130)
Click on image to enlarge
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OCTN1/2/3 (H-130): sc-33534. Western blot analysis of OCTN1/2/3 expression in mouse testis tissue extract.
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