epitope mapping at the C-terminus of CLASP1 of human origin
recommended for detection of CLASP1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
CLASP1 Background Information Members of the CLASP family, including CLASP1, are mammalian microtubule plus-end binding proteins that interact with CLIPs in order to stabilize the microtubule structures in transfected cells. CLASP1 localizes near the distal end of growing spindle microtubules during mitosis and is a component of the outer corona region of kinetochores. CLASP proteins stabilize microtubules by promoting pauses and restricting MT growth. Defects in CLASP1 cause collapse of the spindle, attachment of kinetochores to short microtubules, and other abnormal mitotic behaviors.
