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p-p40-phox Antibody (Thr 154): sc-33403

 |  Datasheet

(Based on data analysis)
  • p-p40-phox Antibody (Thr 154) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to phosphorylated Thr 154 of p40-phox of human origin
  • recommended for detection of Threonine 154 phosphorylated p40-phox of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine and porcine
  • blocking peptide, sc-33403 P
 

See additional p40-phox Antibodies.

Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-p40-phox Antibody (Thr 154) sc-33403 200 µg/ml $279
p-p40-phox (Thr 154) P sc-33403 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p40-phox siRNA (h) sc-36155 10 µM $258
p40-phox siRNA (m) sc-36156 10 µM $258
p40-phox (h)-PR sc-36155-PR 10 µM, 20 µl $23
p40-phox (m)-PR sc-36156-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p40-phox shRNA Plasmid (h) sc-36155-SH 20 µg $520
p40-phox shRNA Plasmid (m) sc-36156-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p40-phox shRNA (h) Lentiviral Particles sc-36155-V 200 µl $625
p40-phox shRNA (m) Lentiviral Particles sc-36156-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NCF4 4689 22q12.3 NM_000631, NM_013416 Q15080
 601488
Mouse Ncf4 17972 15 E1 P97369
 N/A
 

Nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase is a multimeric enzyme system that mediates electron transport from NADPH in the cytoplasm to molecular oxygen in the phagosome, thereby generating reactive oxidant intermediates. Upon neutrophil stimulation, NADPH-oxidase and other cytosolic elements localize to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. There are a number of cytosolic proteins that are involved in NADPH-oxidase activation/ deactivation, including p47-phox, p67-phox, p40-phox and the small GTP-binding protein, Rac. Activation of NADPH oxidase is accompanied by the phosphorylation of cytosolic components p40-phox, p47-phox and p67-phox. The PKC consensus phosphorylation sights Thr 154 and Ser 315 in p40-phox are phosphorylated during activation of NADPH oxidase. p40-phox can promote oxidase activation by increasing the affinity of p47-phox for NADPH-oxidase. However, p40-phox appears to down-regulate oxidase function as well, by competing with an SH3 domain interaction between other essential oxidase components.