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home » Transcription Regulators » Ref-1 Antibody / Ref-1 Antibodies » Ref-1 (C-20): sc-334

Ref-1 (C-20) Antibody: sc-334

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of Ref-1 of human origin
  • recommended for detection of Ref-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-334 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-334 X, 200 µg/0.1 ml
 
Additional Ref-1 Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human APEX1 328 14q11.2 NM_001641, NM_080648, NM_080649 P27695
 107748
Mouse Apex1 11792 14 C1 P28352
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Ref-1 (C-20) sc-334 200 µg/ml $279
Ref-1 (C-20) P sc-334 P
(peptide)
 100 µg/0.5 ml $61
Ref-1 (C-20) X sc-334 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ref-1 siRNA (h) sc-29470 10 µM $258
Ref-1 siRNA (m) sc-36401 10 µM $258
Ref-1 siRNA (r) sc-72399 10 µM $258
Ref-1 (h)-PR sc-29470-PR 10 µM $23
Ref-1 (m)-PR sc-36401-PR 10 µM $23
Ref-1 (r)-PR sc-72399-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ref-1 shRNA Plasmid (h) sc-29470-SH 20 µg $520
Ref-1 shRNA Plasmid (m) sc-36401-SH 20 µg $520
Ref-1 shRNA Plasmid (r) sc-72399-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ref-1 shRNA (h) Lentiviral Particles sc-29470-V 200 µl $625
Ref-1 shRNA (m) Lentiviral Particles sc-36401-V 200 µl $625
Ref-1 shRNA (r) Lentiviral Particles sc-72399-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NIH/3T3 nuclear extract sc-2138 1000 µg $143
KNRK nuclear extract sc-2141 1000 µg $143
Y79 nuclear extract sc-2126 1000 µg $143
C32 nuclear extract sc-2136 1000 µg $143
A-431 nuclear extract sc-2122 1000 µg $143
BJAB Whole Cell Lysate sc-2207 500 µg/200 µl $104
COLO 320DM Cell Lysate sc-2226 500 µg/200 µl $104

Ref-1 Background Information
The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation, evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.

Ref-1 (C-20) Product Citations
See how others have used Ref-1 (C-20): sc-334 antibody and or Ref-1 (C-20) antibody conjugates.


19 total citations
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Ref-1 (C-20)
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sc-334
Ref-1 (C-20): sc-334. Western blot analysis of Ref-1 expression in Y79 (A), HeLa (B), C32 (C) and NIH/3T3 (D) nuclear extracts.
sc-334
Ref-1 (C-20): sc-334. Western blot analysis of Ref-1 expression in KNRK nuclear extract.
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