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p-ATP-citrate synthase (Ser 455) Antibody: sc-33397 |
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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to phosphorylated Ser 455 of ATP-citrate synthase of human origin
- recommended for detection of phosphorylated Ser 455 of ATP-citrate synthase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
- blocking peptide, sc-33397 P
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p-ATP-citrate synthase Background Information ATP-citrate synthase, also designated ATP-citrate lyase or citrate cleavage enzyme, is a cytoplasmic homotetramer belonging to the succinate/malate CoA ligase family. The gene coding for this protein maps against chromosome 17q12-q21. ATP-citrate synthase catalyses the formation of acetyl-CoA and oxaloacetate from citrate and CoA. This product, Acetyl-CoA, is necessary for both fatty acid and cholesterol biosynthesis. ATP citrate-lyase is important in the biosynthesis of acetylcholine in nervous tissue.
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p-ATP-citrate synthase (Ser 455)
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Western blot analysis of ATP-citrate synthase phosphorylation in untreated (A,D), calyculin A treated (B,E) and calyculin A and lambda protein phosphatase ( sc-200312A) treated (C,F) Jurkat whole cell lysates. Antibodies tested is p-ATP-citrate synthase (Ser 455): sc-33397 (A,B,C) and ATP-citrate synthase (C-20): sc-30538 (D,E,F).
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