RB3 (P-17) Antibody: sc-33070

RB3 Background Information
Op18 (for oncoprotein 18, also designated Stathmin, prosolin or metablastin) is a conserved, tubulin-associated, intracellular protein. It serves as a transducing protein, via phosphorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. Op18 is present in many cancers, including breast carcinoma and different leukemias. The neuronal growth-associated protein (nGAP) Stathmin-2, which shares sequence homology with the phosphoprotein Op18/Stathmin-1, is expressed in a variety of neural, immune and reproductive system cell types. Stathmin-2 gene expression is altered in age-related neurodegenerative diseases such as Alzheimer’s disease. Stathmin-4 (also designated Stathmin-like protein B3 or RB3) is a Stathmin-like protein involved in the destabilization of microtubules, specifically in brain tissue. RB3 has a unique N-terminal membrane-associated domain and a Stathmin-like domain at the C-terminus. This C-terminal domain promotes microtubule destabilization and tubulin sequestering.