epitope corresponding to phosphorylated Tyr 724 of FGFR-3 of human origin
recommended for detection of Tyr 724 phosphorylated FGFR-3 of mouse, rat and human origin by WB, IF and ELISA; may cross-react with correspondingly phosphorylated FGFR-1 and FGFR-2; also reactive with additional species, including equine, canine, bovine and avian
FGFR-3 Background Information Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers. Amino acid substitutions within the tyrosine kinase domain activation loop of FGFR-3 result in autophosphorylation of tyrosine residues in the intracellular domain. Phosphorylation at residue Tyr 724 abolishes all FGFR-3 tyrosine phosphorylation.
