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home » Kinases and Phosphatases » PKC Antibody / PKC Antibodies » p-PKC θ (Ser 695): sc-33025

p-PKC θ (Ser 695) Antibody: sc-33025

  |  Datasheet
  • rabbit polyclonal IgG, 200µg/ml
  • epitope corresponding to phosphorylated Ser 695 of PKCθ of mouse origin
  • recommended for detection of Ser 695 phosphorylated p-PKC† of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
  • blocking peptide, sc-33025 P
 
Additional PKC Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PRKCQ 5588 10p15.1 NM_006257 Q04759
 600448
Mouse Prkcq 18761 2 A1 Q02111
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-PKC θ (Ser 695) sc-33025 200 µg/ml $279
p-PKC θ (Ser 695) P sc-33025 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PKC θ siRNA (h) sc-36252 10 µM $258
PKC θ siRNA (m) sc-36247 10 µM $258
PKC θ (h)-PR sc-36252-PR 10 µM $23
PKC θ (m)-PR sc-36247-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PKC θ shRNA Plasmid (h) sc-36252-SH 20 µg $520
PKC θ shRNA Plasmid (m) sc-36247-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PKC θ shRNA (h) Lentiviral Particles sc-36252-V 200 µl $625
PKC θ shRNA (m) Lentiviral Particles sc-36247-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Jurkat + PMA Cell Lysate sc-24718 500 µg/200 µl $104

p-PKC θ Background Information
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes, including conventional (c) PKC isoforms (å, ∫I, ∫II and ©) and novel (n) PKC isoforms (∂, é , Ω, h and †). PKC isoforms can be activated through tyrosine phosphorylation and catalytically activated upon treatment with H2O2. The Tyr 155, 525, 523 and 565 residues in the catalytic domain are crucial for activation of these enzymes. The residue Ser 643 appears to be an autophosphorylation site. PKC theta can undergo autophosphorylation on serine 676 (Ser 676) in the turn loop and serine 695 (Ser 695) in the hydrophobic loop. Phosphorylation of serine 676 may negatively regulate activation of NF-kappa B. Ser-695 is crucial to activate the phosphorylation threonine 692 (Thr 692) and threonine 703 (Thr 703) residues, both of which are necessary for mobility shift.