epitope corresponding to phosphorylated Ser 334 of NFATc4 of human origin
recommended for detection of Ser 334 phosphorylated NFATc4 KTS domain of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
p-NFATc4 Background Information NFATc4 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4) is a member of the nuclear factors of activated T cells DNA-binding transcription complex that influences cytokine gene expression, cardiac hypertrophy, and adipocyte differentiation. This complex consists of at least two components: a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL-2 and IL-4. p38 MAP kinase phosphorylates multiple residues, including Serine 334, in the NFAT homology domain of NFATc4.
