epitope corresponding to phosphorylated Ser 259 of NFATc4 of human origin
recommended for detection of Ser 259 phosphorylated NFATc4 SRR-2/NLS domain of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
NFATc4 Background Information NFATc4 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4) is a member of the nuclear factors of activated T cells DNA-binding transcription complex that influences cytokine gene expression, cardiac hypertrophy, and adipocyte differentiation. This complex consists of at least two components: a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL-2 and IL-4. p38 MAP kinase phosphorylates multiple residues, including Serine 259, in the NFAT homology domain of NFATc4.
