NFATc4 Background Information NFATc4 (nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4) is a member of the nuclear factors of activated T cells DNA-binding transcription complex that influences cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. This complex consists of at least two components: a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL-2 and IL-4. p38 MAP kinase phosphorylates multiple residues in the NFAT homology domain of NFATc4.
NFATc4 (L-9)
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NFATc4 (L-9): sc-32985. Western blot analysis of NFATc4 expression in non-transfected: sc-117752 (A) and human NFATc4 transfected: sc-116481 (B) 293T whole cell lysates.
NFATc4 (L-9): sc-32985. Western blot analysis of NFATc4 expression in non-transfected: sc-117752 (A) and mouse NFATc4 transfected: sc-122039 (B) 293T whole cell lysates.
NFATc4 (L-9): sc-32985. Immunoperoxidase staining of formalin fixed, paraffin-embedded human broncus tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
NFATc4 (L-9): sc-32985. Immunoperoxidase staining of formalin fixed, paraffin-embedded human broncus tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells at low magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
