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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-300 mapping at the N-terminus of Ezrin of human origin
- recommended for detection of Ezrin, Radixin, Moesin, and, to a lesser extent, NF2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
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Ezrin Background Information
Ezrin, Moesin and Radixin belong to a family of highly homologous actin-associated proteins that are localized just beneath the plasma membrane (1). The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins (2-5). Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor (5). Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78 (6). Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types (7,8). Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation (8).
| Ezrin (H-300) Product Citations |
See how others have used Ezrin (H-300): sc-32918 antibody and or Ezrin (H-300) antibody conjugates.
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Ezrin (H-300)
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Ezrin (H-300): sc-32918. Western blot analysis of Ezrin expression in non-transfected: sc-117752 (A) and human Ezrin transfected: sc-170691 (B) 293T whole cell lysates. |
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