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PQBP-1 (FL-265) Antibody: sc-32910 |
| Datasheet |
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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to amino acids 1-265 representing full length PQBP-1 of human origin
- recommended for detection of PQBP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- TransCruz reagent for Gel Supershift and ChIP applications, sc-32910 X, 200 µg/0.1 ml
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PQBP-1 Background Information
Polyglutamine(Q) tract binding protein-1 (PQBP-1) is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders (1-4). Hepta- and di-amino acid repeat sequences rich in polar residues are essential for PQBP-1 to interact with polyglutamine tract-containing proteins (i.e. huntingtin, androgen receptor and Brain-2) (1,2,5). PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling (6,7). PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb (1,3). The human PQBP-1 gene maps to chromosome Xp11.23 (5,8).
| PQBP-1 (FL-265) Product Citations |
See how others have used PQBP-1 (FL-265): sc-32910 antibody and or PQBP-1 (FL-265) antibody conjugates.
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PQBP-1 (FL-265)
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PQBP-1 (FL-265): sc-32910. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.
PQBP-1 (FL-265): sc-32910. Western blot analysis of PQBP-1 expression in non-transfected: sc-117752 (A) and mouse PQBP-1 transfected: sc-122739 (B) 293T whole cell lysates. |
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