epitope corresponding to amino acids 448-747 mapping at the C-terminus of TPX2 of human origin
recommended for detection of TPX2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TPX2 Background Information TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase. Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly. TPX2 appears to play a structural role in spindle formation. TPX2 activates Eg2 in a microtubule-dependent manner by stimulating the phosphorylation and kinase activity
of Eg2. TPX2 is inactivated by binding to importin a, a nuclear import factor. Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.
TPX2 (H-300) Product Citations
See how others have used TPX2 (H-300): sc-32863 antibody and or TPX2 (H-300) antibody conjugates.
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TPX2 (H-300)
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TPX2 (H-300): sc-32863. Western blot analysis of TPX2 expression in K-562 (A) and Jurkat (B) whole cell lysates.
