TACI (1A1) Antibody: sc-32775

TACI Background Information
The NFAT (nuclear factor of activated T cells) family of transcription factors regulates cytokine expression in T cells through cis-acting elements located in the promoters of the cytokine genes (1–5). The NFAT family consists of the cytoplasmic NFAT (NFATc), transcription factors NFATc1, NFATc2, NFATc3 and NFATc4, and nuclear NFAT (NFATn) (6). Each of these transcription factors plays a role in T cell activation (1). CAML (calcium-signal modulating cyclophilin ligand) has been identified as an activator of NFAT and NF-IL2A when overexpressed in Jurkat cells. CAML has also been shown to activate calcineurin by causing calcium influx (7). TACI (transmembrane activator and CAML-interactor), a member of the TNF receptor superfamily, was identified based on its capacity to bind to CAML and has been shown to induce activation of NFAT in the presence of CAML (8).