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p-NF-M (RNF406) Antibody: sc-32727 |
| Datasheet |
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- mouse monoclonal IgG1; 200 µg/ml
- raised against a neurofilament NF-M protein isolated from a cytoskeletal preparation from calf brain
- recommended for detection of phosphorylated NF-M of human, rat and Xenopus origin by WB, IP, IF and IHC(P); also reactive with additional species, including bovine
- fluorescein conjugate for FCM, sc-32727 FITC, 100 tests
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
NEFM |
4741 |
8p21.2 |
NM_005382 |
P07197
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162250 |
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NF-M Background Information
Neurofilament-M (for neurofilament medium polypeptide), or NF-M, a member of the intermediate filament family, is a major component of neuronal cyto-skeletons. Neurofilaments are dynamic structures; they contain phosphoryl-ation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase g. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and Alzheimer’s disease. |
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p-NF-M (RNF406)
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p-NF-M (RNF406): sc-32727. Western blot analysis of NF-M phosphorylation in normal (A) and phospho-protein enriched (B) rat brain tissue extracts.
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