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home » Signaling Intermediates » RKIP Antibody / RKIP Antibodies » p-RKIP (hSer 153): sc-32623

p-RKIP (hSer 153) Antibody: sc-32623

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • recommended for detection of Ser 153 phosphorylated RKIP of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-32623 P
 
Additional RKIP Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PEBP1 5037 12q24.23 NM_002567 P30086
 604591
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-RKIP (hSer 153) sc-32623 200 µg/ml $279
p-RKIP (hSer 153) P sc-32623 P
(peptide)
 100 µg/0.5 ml $61
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RKIP siRNA (h) sc-36430 10 µM $258
RKIP (h)-PR sc-36430-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RKIP shRNA Plasmid (h) sc-36430-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RKIP shRNA (h) Lentiviral Particles sc-36430-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104

RKIP Background Information
Raf kinase inhibitory protein (RKIP, PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. RKIP inhibits MAPK by preventing association of Raf-1 and p21-activated kinase (PAK), and blocking phosphorylation of the Raf-1 kinase domain by PAK and Src kinases. After G protein receptor stimulation, RKIP can dissociate Raf-1 and associate with GRK2, thereby blocking GRK2 activity. This switch is triggered by protein kinase C (PKC)-dependent phosphorylation of the RKIP on Serine 153. RKIP Serine 153 phosphorylation by PKC in response to phorbol ester or epidermal growth factor causes release of RKIP from Raf-1. RKIP antagonizes the signal transduction pathways that mediate the activation of NFkB in response to stimulation with TNF-a or interleukin-1 b.
p-RKIP (hSer 153)
Click on image to enlarge
sc-32623
Western blot analysis of RKIP phosphorylation in untreated (A, C) and lambda protein phosphatase treated (B, D) HL-60 whole cell lysates. Antibodies tested include p-RKIP (hSer 153): sc-32623 (A, B) and RKIP (FL-187): sc-28837 (C, D).
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