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p-RKIP Antibody (hSer 153): sc-32623

 |  Datasheet

(Based on data analysis)

  • p-RKIP Antibody (hSer 153) is a rabbit polyclonal IgG provided at 200 µg/ml
  • recommended for detection of Ser 153 phosphorylated RKIP of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-32623 P
 

See additional RKIP Antibodies.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-RKIP Antibody (hSer 153) sc-32623 200 µg/ml $279
p-RKIP (hSer 153) P sc-32623 P
(peptide)
 100 µg/0.5 ml $61
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
Lambda Phosphatase sc-200312 100000 units in 0.25 ml $462
Lambda Phosphatase sc-200312A 20000 units in 0.05 ml $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
RKIP siRNA (h) sc-36430 10 µM $258
RKIP (h)-PR sc-36430-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
RKIP shRNA Plasmid (h) sc-36430-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
RKIP shRNA (h) Lentiviral Particles sc-36430-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PEBP1 5037 12q24.23 NM_002567 P30086
 604591
 

Raf kinase inhibitory protein (RKIP, PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. RKIP inhibits MAPK by preventing association of Raf-1 and p21-activated kinase (PAK), and blocking phosphorylation of the Raf-1 kinase domain by PAK and Src kinases. After G protein receptor stimulation, RKIP can dissociate Raf-1 and associate with GRK2, thereby blocking GRK2 activity. This switch is triggered by protein kinase C (PKC)-dependent phosphorylation of the RKIP on Serine 153. RKIP Serine 153 phosphorylation by PKC in response to phorbol ester or epidermal growth factor causes release of RKIP from Raf-1. RKIP antagonizes the signal transduction pathways that mediate the activation of NFkB in response to stimulation with TNF-a or interleukin-1 b.
p-RKIP Antibody (hSer 153) Data
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sc-32623
Western blot analysis of RKIP phosphorylation in untreated (A, C) and lambda protein phosphatase treated (B, D) HL-60 whole cell lysates. Antibodies tested include p-RKIP (hSer 153): sc-32623 (A, B) and RKIP (FL-187): sc-28837 (C, D).
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