PP5 Antibody (C-20): sc-32588

---

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. PP5, also designated Protein phosphatase T (PP-T, PPP5C), a predominantly nuclear protein which belongs to the PPP phosphatase family and the PP-T subfamily, interacts with CDC16 and CDC27. It dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1 and may be involved in mitosis and RNA biogenesis regulation.