Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Kinases and Phosphatases » PERK Antibodies » p-PERK Antibody (Thr 981): sc-32577

p-PERK Antibody (Thr 981): sc-32577

 |  Datasheet

(Based on data analysis)

  • p-PERK Antibody (Thr 981) is a rabbit polyclonal IgG provided at 200 µg/ml
  • recommended for detection of Thr 981 phosphorylated PERK of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-32577 P
  • See 26 citations for p-PERK Antibody (Thr 981)
 

See additional PERK Antibodies.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-PERK Antibody (Thr 981) sc-32577 200 µg/ml $279
p-PERK (Thr 981) P sc-32577 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PERK siRNA (h) sc-36213 10 µM $258
PERK siRNA (m) sc-36214 10 µM $258
PERK (h)-PR sc-36213-PR 10 µM, 20 µl $23
PERK (m)-PR sc-36214-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PERK shRNA Plasmid (h) sc-36213-SH 20 µg $520
PERK shRNA Plasmid (m) sc-36214-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PERK shRNA (h) Lentiviral Particles sc-36213-V 200 µl $625
PERK shRNA (m) Lentiviral Particles sc-36214-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human EIF2AK3 9451 2p11.2 NM_004836 Q9NZJ5
 604032
Mouse Eif2ak3 13666 6 C1 Q9Z2B5
 N/A
 

PERK (eukaryotic translation initiation factor 2-alpha kinase 3, eIF2å kinase 3, PEK, WRS) is a Ser/Thr protein kinase, type I membrane protein of the endoplasmic reticulum that is abundant in secretory tissues and is inducible by ER-stress. PERK phosphorylates the å subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, a reduction of translation initiation and repression of global protein synthesis. PERK may serve as an effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. PERK dimerizes with HSPA5/BIP in resting cells and oligomerizes in ER-stressed cells. Perturbation in protein folding in the endoplasmic reticulum (ER) can promote dissociation from HSPA5/BIP and oligomerization, resulting in autophosphorylation and kinase activity induction.

p-PERK Antibody (Thr 981) Product Citations
See how others have used p-PERK Antibody (Thr 981) and or p-PERK Antibody (Thr 981) conjugates.


26 total citations
Loading citations.
 
p-PERK Antibody (Thr 981) Data
Click on image to enlarge
sc-32577
p-PERK (Thr 981): sc-32577. Western blot analysis of PERK phosphorylation in HeLa (A) and Thapsigargin treated HeLa (B) whole cell lysates.
Download
Datasheets
Get Adobe Acrobat Reader