epitope corresponding to phosphorylated Ser 24 of Dab2 of human origin
recommended for detection of Ser 24 phosphorylated Dab2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
Dab2 Background Information Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, and it is thought to be a negative regulator of growth. Dab2 Ser24 phosphorylation promotes membrane translocation of Dab2 and its subsequent interaction with integrin beta3, thereby defining a mechanism for Dab2 in regulating CD61 activation and inside-out signaling. Dab2 Ser24 phosphorylation is also involved in the negative regulation of CD61-induced T cell factor (TCF) transcriptional activity. Dab2 elicits distinct regulatory mechanisms in CD61 and -catenin/plakoglobin signaling in a Ser24 phosphorylation-dependent and -independent manner, respectively. Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development.
p-Dab2 (Ser 24) Product Citations
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p-Dab2 (Ser 24)
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p-Dab2 (Ser 24): sc-32573. Western blot analysis of Dab2 phosphorylation in non-transfected 293T: sc-117752 (A), mouse Dab2 transfected 293T: sc-119652 (B) and Y79 (C) whole cell lysates.
p-Dab2 (Ser 24): sc-32573. Western blot analysis of Dab2 phosphorylation in non-transfected: sc-117752 (A) and human Dab2 transfected: sc-172931 (B) 293T whole cell lysates.
p-Dab2 (Ser 24): sc-32573. Western blot analysis of Dab2 phosphorylation in untreated (A) and lambda protein phosphatase treated HeLa whole cell lysates (B).
