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home » Transcription Regulators » ICSBP Antibody / ICSBP Antibodies » ICSBP (T-14): sc-32528

ICSBP (T-14) Antibody: sc-32528

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping within an internal region of ICSBP of mouse origin
  • recommended for detection of ICSBP of mouse and rat origin by WB, IP, IF and ELISA
  • blocking peptide, sc-32528 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-32528 X, 200 µg/0.1 ml
 
Additional ICSBP Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Irf8 15900 8 E1 P23611
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
ICSBP (T-14) sc-32528 200 µg/ml $279
ICSBP (T-14) P sc-32528 P
(peptide)
 100 µg/0.5 ml $61
ICSBP (T-14) X sc-32528 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ICSBP siRNA (m) sc-35631 10 µM $258
ICSBP (m)-PR sc-35631-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ICSBP shRNA Plasmid (m) sc-35631-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
ICSBP shRNA (m) Lentiviral Particles sc-35631-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
RAW 264.7 + IFN-γ Cell Lysate sc-2259 500 µg/200 µl $104

ICSBP Background Information
ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-©-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-© and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-å and IFN-∫.

ICSBP (T-14)
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sc-32528
ICSBP (T-14): sc-32528. Western blot analysis of ICSBP expression in IB4 (A), M1 (B), IFN-γ-induced RAW 264.7 (C) and untreated RAW 264.7 (D) whole cell lysates.
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