santa cruz biotechnology, inc.
| |
|
 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of ICSBP of mouse origin
- recommended for detection of ICSBP of mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- blocking peptide, sc-32527 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-32527 X, 200 µg/0.1 ml
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
Irf8 |
15900 |
8 E1 |
|
P23611
|
N/A |
| |
ICSBP Background Information
ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-©-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-© and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-å and IFN-∫. |
|
|
ICSBP (E-12)
Click on image to enlarge
|
|
ICSBP (E-12): sc-32527. Western blot analysis of ICSBP expression in mouse spleen tissue extract.
|
|
Download
|
| |
