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A20 Antibody (E-18): sc-32523

 |  Datasheet

(Based on data analysis)
  • A20 Antibody (E-18) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the N-terminus of A20 of human origin
  • recommended for detection of A20 of mouse and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-32523 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-32523 X, 200 µg/0.1 ml
 

See additional A20 Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   Gel Shift   ChIP   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
A20 Antibody (E-18) sc-32523 200 µg/ml $279
A20 (E-18) P sc-32523 P
(peptide)
 100 µg/0.5 ml $61
A20 Antibody (E-18) X sc-32523 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A20 siRNA (h) sc-37655 10 µM $258
A20 siRNA (m) sc-37656 10 µM $258
A20 (h)-PR sc-37655-PR 10 µM, 20 µl $23
A20 (m)-PR sc-37656-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A20 shRNA Plasmid (h) sc-37655-SH 20 µg $520
A20 shRNA Plasmid (m) sc-37656-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A20 shRNA (h) Lentiviral Particles sc-37655-V 200 µl $625
A20 shRNA (m) Lentiviral Particles sc-37656-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Daudi Cell Lysate sc-2415 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
U-937 + TNFα Cell Lysate sc-2297 500 µg/200 µl $104
U-937 Cell Lysate sc-2239 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TNFAIP3 7128 6q23.3 NM_006290 P21580
 191163
Mouse Tnfaip3 21929 10 A3 Q60769
 N/A
 

A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IκB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.