 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of NPAT of human origin
- recommended for detection of NPAT of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-32359 P
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
NPAT |
4863 |
11q22.3 |
NM_002519 |
Q14207
|
601448 |
| Mouse |
Npat |
244879 |
9 A5.3 |
|
Q8BMA5
|
N/A |
| |
NPAT Background Information
The nuclear protein, ataxia telangiectasia locus (NPAT), an essential downstream component of the cyclin E/Cdk2 signaling pathway, acts as a critical regulator for S-phase entry, histone gene expression and Cajal body maintenance in somatic cells. This protein was originally identified by its chromosomal location, 11q23, and its proximity to the Atm gene, which is responsible for the autosomal recessive disease ataxia telangiectasia (AT). The NPAT protein sequence is strongly conserved in eukaryotes and its expression is ubiquitous. The C-terminal half of the NPAT protein contains multiple elements required for induction of S phase, while the N-terminal half appears to be crucial for the activation of histone H4 and H2B. NPAT contains several Cdk2 phosphorylation sites, but they do not appear to affect protein function. |
|
|
NPAT (C-19)
Click on image to enlarge
|
|
NPAT (C-19): sc-32359. Western blot analysis of NPAT expression in mouse testis tissue extract.
|
|
Download
|
|
