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SorCS1 Antibody (D-20): sc-32340

 |  Datasheet

(Based on data analysis)
  • SorCS1 Antibody (D-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of SorCS1 of mouse origin
  • recommended for detection of isoforms 1-4 of precursor and mature SorCS1 of mouse, rat and human origin by WB, IF and ELISA; may cross-react with SorCS3 of mouse origin; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-32340 P
 

See additional SorCS Antibodies including SorCS, SorCS1, SorCS3 and SorCS2.

Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
SorCS1 Antibody (D-20) sc-32340 200 µg/ml $279
SorCS1 (D-20) P sc-32340 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SorCS1 siRNA (h) sc-44745 10 µM $258
SorCS1 (h)-PR sc-44745-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SorCS1 shRNA Plasmid (h) sc-44745-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SorCS1 shRNA (h) Lentiviral Particles sc-44745-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SORCS1 114815 10q25.1 NM_001013031, NM_052918 Q8WY21
 606283
Mouse Sorcs1 58178 19 D1 Q9JLC4
 N/A
 

There are three sorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, the homologous SorCS1 and SorCS2 genes and the SorCS3 gene are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS1 is a type 1 receptor containing a VPS10P domain and a leucine-rich domain. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic tails and differential expression in tissues. Human SorCS1 is detected in fetal and infant brain and in fetal retina. Alternative splicing of murine SorCS1 also results in four isoforms. Murine isoform 1 is highly expressed in brain and at lower levels in heart, liver and kidney. It is detected in newborn mouse brain and in adult olfactory bulb and cerebral cortex. Murine isoform 2 is highly expressed in liver and at lower levels in heart, brain, kidney and testis.