TCL-1A (1-21) Antibody: sc-32331

TCL-1A Background Information
T-cell Leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL) (1-5). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.1 (1-5). TCL-1A is a member of a unique family of beta barrel proteins that bind small hydrophobic ligands and function in cell regulation (2). TCL-1A is an all-beta protein containing an eight-stranded antiparallel beta barrel which consists of two four-stranded beta-meander motifs (3). The two motifs are related by a twofold axis and connected by a long loop. TCL-1A forms a tight crystallographic dimer (3). TCL-1A is expressed in pre-B cells, in immature thymocytes, at low levels in activated T cells, and in the cytoplasm (3,4).