hnRNP U Background Information RNA polymerase II transcripts are complexed with hnRNP (heterogeneous nuclear ribonucleoprotein) proteins, which are involved in several aspects of hnRNA maturation and transport. The hnRNP particle U (also designated SP120 and SAF-A for scaffold attachment factor) is an abundant nucleoplasmic phosphoprotein and the largest of the major hnRNP proteins. hnRNP U is specifically involved in pre-mRNA processing and is directly bound to both RNA and DNA. Specifically, hnRNP U has a high affinity to the SAR (scaffold attachment region) of DNA . hnRNP U also functions as an RNA polymerase elongation inhibitor by inhibiting TFIIH-mediated phosphorylation of the carboxy-terminal domain of Pol II. Identical to GRIP120, hnRNP U also associates with glucocorticoid receptors to inhibit glucocorticoid induction.
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hnRNP U (3G6)
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hnRNP U (3G6): sc-32315. Western blot analysis of hnRNP U expression in K-562 (A), HeLa (B) and Jurkat (C) nuclear extracts.
hnRNP U (3G6): sc-32315. Western blot analysis of hnRNP U expression in K-562 (A), HeLa (B) and Jurkat (C) nuclear extracts.
hnRNP U (3G6): sc-32315. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
hnRNP U (3G6): sc-32315. Western blot analysis of hnRNP U expression in non-transfected 293T: sc-117752 (A), human hnRNP U transfected 293T: sc-113957 (B) and K-562 (C) whole cell lysates.
hnRNP U (3G6): sc-32315. Western blot analysis of hnRNP U expression in non-transfected: sc-117752 (A) and human hnRNP U transfected: sc-113957 (B) 293T whole cell lysates and K-562 nuclear extract (C).
