p-CKR-5 Antibody (V14/2): sc-32303

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C-C or b chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells (1). C-C chemokine receptor family members include, CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen (2,3,7,8). Each of these receptors are G-protein coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation (3-5). However, this receptor family has also been shown to facilitate viral infection. Termed a “coreceptor”, CKR-5, along with CD4, has been shown to be a major receptor for HIV (1-6). CKR-5 tends to associate with macrophage-tropic viruses, such as macrophage tropic HIV-1, while CKR-2B and CKR-3 bind a minority of viruses (6). Agonist binding to the CKR-5 induces the phosphorylation of four distinct serine residues that are located in the CKR-5 carboxy terminus. This terminus is involved in the coupling to G-proteins and also contains a cysteine site along with the phosphorylation sites, and all are involved in receptor desensitization.