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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Flt-4 of human origin
- recommended for detection of Flt-4 p170 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- blocking peptide, sc-321 P
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Flt-4 Background Information
Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1) (1–3), Flk-1 (also designated VEGF-R2) (4–6) and Flt-4 (also designated VEGF-R3) (7), putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs) (3,5). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand (7).
| Flt-4 (C-20) Product Citations |
See how others have used Flt-4 (C-20): sc-321 antibody and or Flt-4 (C-20) antibody conjugates.
29 total citations Loading citations.
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Flt-4 (C-20)
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Western blot analysis of Flt-4 expression in K-562 whole cell lysate (A) and rat liver extract (B). Antibodies tested include Flt-4 (C-20): sc-321 (A) and Flt-4 (M-20): sc-637 (B). Flt-4 (C-20): sc-321. Immunofluorescence staining of methanol-fixed K-562 cells showing membrane and cytoplasmic localization.
Flt-4 (C-20): sc-321. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane and cytoplasmic localization.
Flt-4 (C-20): sc-321. Western blot analysis of Flt-4 expression in HEL 92.1.7 whole cell lysate.
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